Keeping a band together is a tricky thing. Like any business, it is a rare band that can weather touring, fame, and excess without some "restructuring" of their personnel. While Led Zeppelin managed an entire career with its original lineup intact (for their recent LZ reunion show, the late John Bonham was classily replaced by his own son), more likely is the case where at least one or two members reach their rock 'n' roll omega point and call it a day, often citing one of the big three: family, creative differences, or asphyxiation. At the far end of the rainbow, we find those exceptional collectives who just hemorrhage bandmates. Here are 5 bands down to one (or none) of their original members.
5. Megadeth
For all the fun we had watching Metallica air out their dirty laundry in Some Kind of Monster, the full story of Megadeth--founded by guitarist and sole remaining member Dave Mustaine after being ousted from Metallica--is a far crazier one. A staggering 20 musicians have passed through Megadeth's ranks mostly due to drugs, creative differences, and drugs. About 7 years into their career the band solidified with what is widely regarded as its strongest lineup. After a decade long run however, that too eventually fizzled. Although Mustaine invited this beloved lineup to reunite at one point, all have thus far proved unavailable for the occasion. Their reasons? Lead guitarist Marty Friedman is busy with his J-pop career, drummer Nick Menza pretended to have cancer, and bassist Dave Ellefson is living off of an inheritance from the late L. Ron Hubbard (FYI, I only made up ONE of those). Now with a band of ringers in tow, Mustaine continues to tour the world as Megadeth, mostly playing countries that probably never knew what the guys in Megadeth looked like in the first place. Here's the new lineup performing "Peace Sells", the intro of which they licensed up the wazoo for MTV News:

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